Publications
|| - these authors contributed equally to this work2024
C. Xia, D. Colognori, X. Jiang, K. Xu, J. A. Doudna, "Single-molecule live-cell RNA imaging with CRISPR-Csm," [Link] |
A. A. Choi, C. Y. Zhou, A. Tabo, R. Heald, K. Xu, "Single-molecule diffusivity quantification in Xenopus egg extracts elucidates physicochemical properties of the cytoplasm," [Link] |
B. A. Unger, C. Y. Wu, A. A. Choi, C. He, K. Xu, "Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion," [Link] |
A. A. Choi, K. Xu, "Single-molecule diffusivity quantification unveils ubiquitous net charge-driven protein-protein interaction," [Link] [Science blog by Derek Lowe] |
M. A. Steves, C. He, K. Xu, "Single-molecule spectroscopy and super-resolution mapping of physicochemical parameters in living cells," [Invited Review] [Link] |
H.-J. Cha||, C. He||, D. J. Glover, K. Xu, D. S. Clark, "STORM super-resolution visualization of self-assembled γPFD chaperone ultrastructures in Methanocaldococcus jannaschii," [Link] |
K. Rose, T. Jepson, S. Shukla, A. Maya-Romero, M. Kampmann, K. Xu, J. H. Hurley, "Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes," [Link] |
M. A. Steves, K. Xu, "Mapping super-resolution image quality," [News & Views] [Link] |
2023
C. He, C. Y. Wu, W. Li, K. Xu, "Multidimensional super-resolution microscopy unveils nanoscale surface aggregates in the aging of FUS condensates," [Link] [Cover] |
A. A. Choi, L. Xiang, W. Li, K. Xu, "Single-molecule displacement mapping indicates unhindered intracellular diffusion of small (<~1 kDa) solutes," [Link] |
H. H. Park, A. A. Choi, K. Xu, "Size-dependent suppression of molecular diffusivity in expandable hydrogels: A single-molecule study," [Link] [Xiaoliang Sunney Xie Festschrift] |
H. H. Park, B. Wang, S. Moon, T. Jepson, K. Xu, "Machine-learning-powered extraction of molecular diffusivity from single-molecule images for super-resolution mapping," [Link] |
L. Xiang, R. Yan, K. Chen, W. Li, K. Xu, "Single-molecule displacement mapping unveils sign-asymmetric protein charge effects on intraorganellar diffusion," [Link] |
D. S. Kang, A. Moriarty, Y. J. Wang, A. Thomas, J. Hao, B. A. Unger, R. Klotz, S. Ahmmed, Y. Amzaleg, S. Martin, S. Vanapalli, K. Xu, A. Smith, K. Shen, M. Yu, "Ectopic expression of a truncated isoform of hair keratin 81 in breast cancer alters biophysical characteristics to promote metastatic propensity," [Link] |
I. C. Becker, A. R. Wilkie, B. A. Unger, A. R. Sciaudone, F. Fatima, I. T. Tsai, K. Xu, K. R. Machlus, J. E. Italiano, "Dynamic actin/septin network in megakaryocytes co-ordinates proplatelet elaboration," [Link] |
R. Yuan, T. D. Roberts, R. M. Brinn, A. A. Choi, H. H. Park, C. Yan, J. C. Ondry, S. Khorasani, D. J. Masiello, K. Xu, A. P. Alivisatos, N. S. Ginsberg, "A composite electrodynamic mechanism to reconcile spatiotemporally resolved exciton transport in quantum dot superlattices," [Link] |
W. M. Skinner, N. T. Petersen, B. Unger, S. Tang, E. Tabarsi, J. Lamm, L. Jalalian, J. Smith, A. M. Bertholet, K. Xu, Y. Kirichok, P. V. Lishko, "Mitochondrial uncouplers impair human sperm motility without altering ATP content," [Link] |
V. Nguyen, W. Li, J. Ager, K. Xu, H. Taylor, "Optical reflectance imaging reveals interlayer coupling in mechanically stacked MoS2 and WS2 bilayers," [Link] |
2022
W. Li||, Y. Li||, B. Wang, K. Xu, "Visible-light azidation and chemical patterning of graphene via photoredox catalysis," [Link] |
K. Chen, W. Li, K. Xu, "Super-multiplexing excitation spectral microscopy with multiple fluorescence bands," [Link] |
I. O. Aparin||, R. Yan||, R. Pelletier, A. A. Choi, D. I. Danylchuk, K. Xu, A. S. Klymchenko, "Fluorogenic dimers as bright switchable probes for enhanced super-resolution imaging of cell membranes," [Link] |
W. M. Śmigiel, L. Mantovanelli, D. S. Linnik, M. Punter, J. Silberberg, L. Xiang, K. Xu, B. Poolman, "Protein diffusion in Escherichia coli cytoplasm scales with the mass of the complexes and is location dependent," [Link] |
M. Jin, C. Shirazinejad, B. Wang, A. Yan, J. Schöneberg, S. Upadhyayula, K. Xu, D. G. Drubin, "Branched actin networks are organized for asymmetric force production during clathrin-mediated endocytosis in mammalian cells," [Link] |
B. Wang, Z. Zhao, M. Xiong, R. Yan, K. Xu, "The endoplasmic reticulum adopts two distinct tubule forms," [Link] |
C. Kaplan, S. J. Kenny, X. Chen, J. Schöneberg, E. Sitarska, A. Diz-Muñoz, M. Akamatsu, K. Xu, D. G. Drubin, "Load adaptation by endocytic actin networks," [Link] [Cover] |
Y. Li, B. Wang, W. Li, K. Xu, "Dynamic, spontaneous blistering of substrate-supported graphene in acidic solutions," [Link] [Cover] |
A. A. Choi, H. H. Park, K. Chen, R. Yan, W. Li, K. Xu, "Displacement statistics of unhindered single molecules show no enhanced diffusion in enzymatic reactions," [Link] |
R. Yan, K. Chen, B. Wang, K. Xu, "SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport," [Link] |
B. Wang, M. Xiong, J. Susanto, X. Li, W.-Y. Leung, K. Xu, "Transforming rhodamine dyes for (d)STORM super-resolution microscopy via 1,3-disubstituted imidazolium substitution," [Link] |
F. Hu, D. Zhu, H. Dong, P. Zhang, F. Xing, W. Li, R. Yan, J. Zhou, K. Xu, L. Pan, J. Xu, "Super-resolution microscopy reveals nanoscale architecture and regulation of podosome clusters in primary macrophages," [Link] |
Z. L. Newman, D. Bakshinskaya, R. Schultz, S. J. Kenny, S. Moon, K. Aghi, C. Stanley, N. Marnani, R. Li, J. Bleier, K. Xu, E. Y. Isacoff, "Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging," [Link] |
2021
L. Xiang||, K. Chen||, K. Xu, "Single molecules are your quanta: A bottom-up approach toward multidimensional super-resolution microscopy," [Invited Perspective] [Link] |
K. Chen, R. Yan, L. Xiang, K. Xu, "Excitation spectral microscopy for highly multiplexed fluorescence imaging and quantitative biosensing," [Link] |
S. Li, R. Yan, J. Xu, S. Zhao, X. Ma, Q. Sun, M. Zhang, Y. Li, J.-J. G. Liu, L. Chen, S. Li, K. Xu, L. Ge, "A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis," [Link] |
R. Tian, A. Abarientos, J. Hong, S. H. Hashemi, R. Yan, N. Dräger, K. Leng, M. A. Nalls, A. B. Singleton, K. Xu, F. Faghri, M. Kampmann, "Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis," [Link] |
M. E. Truong, S. Bilekova, S. P. Choksi, W. Li, L. J. Bugaj, K. Xu, J. F. Reiter, "Vertebrate cells differentially interpret ciliary and extraciliary cAMP," [Link] |
W. Li, Y. Li, K. Xu, "Facile, electrochemical chlorination of graphene from an aqueous NaCl solution," [Link] |
2020
R. Yan, K. Chen, K. Xu, "Probing nanoscale diffusional heterogeneities in cellular membranes through multidimensional single-molecule and super-resolution microscopy," [Link] |
B. Belardi, T. Hamkins-Indik, A. R. Harris, J. Kim, K. Xu, D. A. Fletcher, "A weak link with actin organizes tight junctions to control epithelial permeability," [Link] |
T. D. Roberts, R. Yuan, L. Xiang, M. Delor, R. Pokhrel, K. Yang, E. Aqad, T. Marangoni, P. Trefonas, K. Xu, N. S. Ginsberg, "Direct correlation of single-particle motion to amorphous microstructural components of semicrystalline poly(ethylene oxide) electrolytic films," [Link] |
K. J. Wolf, P. Shukla, K. Springer, S. Lee, J. D. Coombes, C. J. Choy, S. J. Kenny, K. Xu, S. Kumar, "A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles," [Link] |
S. Moon||, W. Li||, M. Hauser, K. Xu, "Graphene-enabled, spatially controlled electroporation of adherent cells for live-cell super-resolution microscopy," [Link] |
L. Xiang||, K. Chen||, R. Yan, W. Li, K. Xu, "Single-molecule displacement mapping unveils nanoscale heterogeneities in intracellular diffusivity," [Link] |
X. Guo, G. Aviles, Y. Liu, R. Tian, B. A. Unger, Y.-H. T. Lin, A. P. Wiita, K. Xu, M. A. Correia, M. Kampmann, "Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway," [Link] |
S. Köhler||, M. Wojcik||, K. Xu, A. F. Dernburg, "The interaction of crossover formation and the dynamic architecture of the synaptonemal complex during meiosis," [Link] |
W. Li, Y. Li, K. Xu, "Azidated graphene: direct azidation from monolayers, click chemistry, and bulk production from graphite," [Link] |
2019
S. J. Kenny||, X. S. Chen||, L. Ge, K. Xu, "Super-resolution microscopy unveils FIP200-scaffolded, cup-shaped organization of mammalian autophagic initiation machinery," [Link] |
Y. Sun, J. Schöneberg, X. Chen, T. Jiang, C. Kaplan, K. Xu, T. D. Pollard, D. G. Drubin, "Direct comparison of clathrin-mediated endocytosis in budding and fission yeast reveals conserved and evolvable features,"[Link] |
L. Xiang, K. Xu, "Super-resolution writing," [News & Views] [Link] |
P. D. Sohn, C. T.-L. Huang, R. Yan, L. Fan, T. E. Tracy, C. M. Camargo, K. M. Montgomery, T. Arhar, S.-A. Mok, R. Freilich, J. Baik, M. He, S. Gong, E. D. Roberson, C. M. Karch, J. E. Gestwicki, K. Xu, K. S. Kosik, L. Gan, "Pathogenic tau impairs axon initial segment plasticity and excitability homeostasis," [Link] |
J. Kim, M. Wojcik, Y. Wang, S. Moon, E. A. Zin, N. Marnani, Z. L. Newman, J. G. Flannery, K. Xu, X. Zhang, "Oblique-plane single-molecule localization microscopy for tissues and small intact animals," [Link] |
D. I. Danylchuk||, S. Moon||, K. Xu, A. S. Klymchenko, "Switchable solvatochromic probes for live-cell super-resolution imaging of plasma membrane organization," [Link] |
Y. Li, W. Li, M. Wojcik, B. Wang, L.-C. Lin, M. B. Raschke, K. Xu, "Light-assisted diazonium functionalization of graphene and spatial heterogeneities in reactivity," [Link] |
R. Yan, B. Wang, K. Xu, "Functional super-resolution microscopy of the cell," [Invited review] [Link] |
L. Pan, P. Zhang, F. Hu, R. Yan, M. He, W. Li, J. Xu, K. Xu, "Hypotonic stress induces fast, reversible degradation of the vimentin cytoskeleton via intracellular calcium release," [Link] |
T. Kim||, S. Moon||, K. Xu, "Information-rich localization microscopy through machine learning," [Link] |
A. A. Polyzos, D. Y. Lee, R. Datta, M. Hauser, H. Budworth, A. Holt, S. Mihalik, P. Goldschmidt, K. Frankel, K. Trego, M. J. Bennett, J. Vockley, K. Xu, E. Gratton, C. T. McMurray, "Metabolic reprogramming in astrocytes distinguishes region-specific neuronal susceptibility in Huntington mice," [Link] |
W. Li, M. Wojcik, K. Xu, "Optical microscopy unveils rapid, reversible electrochemical oxidation and reduction of graphene," [Link] |
2018
L. Yuan, S. J. Kenny, J. Hemmati, K. Xu, R. Schekman, "TANGO1 and SEC12 are copackaged with procollagen I to facilitate the generation of large COPII carriers," [Link] |
M. R. Miller||, S. J. Kenny||, N. Mannowetz||, S. A. Mansell, M. Wojcik, S. Mendoza, R. S. Zucker, K. Xu, P. V. Lishko, "Asymmetrically positioned flagellar control units regulate human sperm rotation," [Link] |
M. Hauser, R. Yan, W. Li, N. A. Repina, D. V. Schaffer, K. Xu, "The spectrin-actin-based periodic cytoskeleton as a conserved nanoscale scaffold and ruler of the neural stem cell lineage," [Link] |
D. Joshi||, M. Hauser||, G. Veber, A. Berl, K. Xu, F. R. Fischer, "Super-resolution imaging of clickable graphene nanoribbons decorated with fluorescent dyes," [Link] |
L. Xiang, M. Wojcik, S. J. Kenny, R. Yan, S. Moon, W. Li, K. Xu, "Optical characterization of surface adlayers and their compositional demixing at the nanoscale," [Link] |
V. Serpooshan||, S. Sheibani||, P. Pushparaj||, M. Wojcik||, A. Y. Jang||, M. R. Santoso, J. H. Jang, H. Huang, R. Safavi-Sohi, N. Haghjoo, H. Nejadnik, H. Aghaverdi, H. Vali, J. M. Kinsella, J. Presley, K. Xu, P. C.-M. Yang, M. Mahmoudi, "Effect of cell sex on uptake of nanoparticles: the overlooked factor at the nanobio interface," [Link] |
R. Yan||, S. Moon||, S. J. Kenny||, K. Xu, "Spectrally resolved and functional super-resolution microscopy via ultrahigh-throughput single-molecule spectroscopy," [Invited review] [Link] |
L. Pan, R. Yan, W. Li, K. Xu, "Super-resolution microscopy reveals the native ultrastructure of the erythrocyte cytoskeleton," [Link] |
M. Jacko, S. M. Weyn-Vanhentenryck, J. W. Smerdon, R. Yan, H. Feng, D. J. Williams, J. Pai, K. Xu, H. Wichterle, C. Zhang, "Rbfox splicing factors promote neuronal maturation and axon initial segment assembly,"[Link] |
2017
C. L. Hueschen, S. J. Kenny, K. Xu, S. Dumont, "NuMA recruits dynein activity to microtubule minus-ends at mitosis," [Link] |
S. Moon||, R. Yan||, S. J. Kenny, Y. Shyu, L. Xiang, W. Li, K. Xu, "Spectrally resolved, functional super-resolution microscopy reveals nanoscale compositional heterogeneity in live-cell membranes," [Link] |
D. Kim, Z. Zhang, K. Xu, "Spectrally resolved super-resolution microscopy unveils multipath reaction pathways of single spiropyran molecules, "[Link] |
P. G. Cao||, P. Bai||, A. A. Omrani||, Y. Xiao, K. L. Meaker, H.-Z. Tsai, A. Yan, H. S. Jung, R. Khajeh, G. F. Rodgers, Y. Kim, A. S. Aikawa, M. A. Kolaczkowski, Y. Liu, A. Zettl, K. Xu, M. F. Crommie, T. Xu, "Preventing thin film dewetting via graphene capping, "[Link] |
L. Ge, M. Zhang, S. J. Kenny, D. Liu, M. Maeda, K. Saito, A. Mathur, K. Xu, R. Schekman, "Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis, "[Link] |
T. Heydari, M. Heidari, O. Mashinchian, M. Wojcik, K. Xu, M. J. Dalby, M. Mahmoudi, M. R. Ejtehadi, "Development of a virtual cell model to predict cell response to substrate topography, "[Link] |
S. Köhler||, M. Wojcik||, K. Xu, A. F. Dernburg, "Superresolution microscopy reveals the three-dimensional organization of meiotic chromosome axes in intact Caenorhabditis elegans tissue, "[Link] |
A. Gorur, L. Yuan, S. J. Kenny, S. Baba, K. Xu, R. Schekman, "COPII-coated membranes function as transport carriers of intracellular procollagen-I," [Link] |
M. Wojcik||, Y. Li||, W. Li, K. Xu, "Spatially resolved in situ reaction dynamics of graphene via optical microscopy,"[Link] |
A. N. Killilea, R. Csencsits, E. Le, A. M. Patel, S. J. Kenny, K. Xu, K. H. Downing, "Cytoskeletal organization in microtentacles," [Link] |
M. Hauser||, M. Wojcik||, D. Kim||, M. Mahmoudi, W. Li, K. Xu, "Correlative super-resolution microscopy: new dimensions and new opportunities," [Invited review] [Link] |
2016
D. M. Jorgens||, J. L. Inman||, M. Wojcik||, C.Robertson||, H. Palsdottir, W. T. Tsai, H. Huang, A. Bruni-Cardoso, C. S. Lopez, M. J. Bissell, K. Xu, M. Auer, "Deep nuclear invaginations linked to cytoskeletal filaments: Integrated bioimaging of epithelial cells in 3D culture,"[Link] |
W. Li||, S. Moon||, M. Wojcik||, K. Xu, "Direct optical visualization of graphene and its nanoscale defects on transparent substrates,"[Link] |
2015
M. Zhang, S. J. Kenny, L. Ge, K. Xu, R. Schekman, "Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion,"[Link] |
Z. Zhang, S. J. Kenny, M. Hauser, W. Li, K. Xu, "Ultrahigh-throughput single-molecule spectroscopy and spectrally resolved super-resolution microscopy," [Link] |
M. Wojcik||, M. Hauser||, W. Li, S. Moon, K. Xu, "Graphene-enabled electron microscopy and correlated super-resolution microscopy of wet cells," [Link] |
K. Xu, J. R. Heath, "Contact with what?" [News & Views] |
Previous work
D. Blunk, Y. Akbergenova, R. W. Cho, J. Lee, U. Walldorf, K. Xu, G. Zhong, X. Zhuang, and J. T. Littleton, "Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction," |
K. Xu, G. Zhong, and X. Zhuang, "Actin, spectrin, and associated proteins form a periodic
cytoskeletal structure in axons" |
K. Xu, S.-H. Shim, and X. Zhuang, "Super-resolution imaging through stochastic switching and localization of single molecules: an overview" |
K. Xu, H.P. Babcock, and X. Zhuang, "Dual-objective STORM reveals three-dimensional filament organization in the actin cytoskeleton" |
P. G. Cao, J. O. Varghese, K. Xu, and J. R. Heath, "Visualizing local doping effects of individual
water clusters on gold(111)-supported graphene," |
P. G. Cao, K. Xu, J. O. Varghese, and J. R. Heath, "The microscopic structure of adsorbed water on hydrophobic surfaces under ambient conditions" |
P. G. Cao, K. Xu, J. O. Varghese, and J. R. Heath, "Atomic force microscopy characterization of
room-temperature adlayers of small organic molecules through graphene templating," |
K. Xu, P. G. Cao, and J.R. Heath, "Graphene visualizes the first water adlayers on mica at ambient conditions" |
K. Xu, P. G. Cao, and J. R. Heath, "Achieving the theoretical depairing current limit in superconducting nanomesh films" |
K. Xu, P. G. Cao, and J. R. Heath, "The crossover from two dimensions to one dimension in granular electronic materials" |
K. Xu, P. G. Cao, and J. R. Heath, "Scanning tunneling microscopy characterization of the electrical properties of wrinkles in exfoliated graphene monolayers" |
K. Xu, J.R. Heath, "Long, highly-ordered high-temperature superconductor nanowire arrays" |
K. Xu, P. G. Cao, and J. R. Heath, "Controlled fabrication and electrical properties of long quasi-one-dimensional superconducting nanowire arrays" |
P. G. Cao, K. Xu, and J. R. Heath, "Azidation of silicon(111) surfaces," |
K. Xu, J. E. Green, J. R. Heath, F. Remacle, and R. D. Levine, "The emergence of a coupled quantum dot array in a doped silicon nanowire gated by ultrahigh density top gate electrodes" |
J. E. Green, J. W. Choi, A. Boukai, Y. Bunimovich, E. Johnston-Halperin, E. Delonno, Y. Luo, B. A. Sheriff, K. Xu, Y. S. Shin, H. R. Tseng, J. F. Stoddart, and J. R. Heath, "A 160-kilobit molecular electronic memory patterned at 1011 bits per square centimetre," |
A. Boukai, K. Xu, and J. R. Heath, "Size-dependent transport and thermoelectric properties of individual polycrystalline bismuth nanowires," |
J. W. Choi, A. H. Flood, D. W. Steuerman, S. Nygaard, A. B. Braunschweig, N. N. P. Moonen, B. W. Laursen, Y. Luo, E. DeIonno, A. J. Peters, J. O. Jeppesen, K. Xu, J. F. Stoddart, and J. R. Heath, "Ground-state equilibrium thermodynamics and switching kinetics of bistable [2]rotaxanes switched in solution, polymer gels, and molecular electronic devices," |
Z. Y. Zhang, K. Xu, W. R. G. Baeyens, and X. R. Zhang, "An energy-transfer cataluminescence reaction on nanosized catalysts and its application to chemical sensors," |
Z. Y. Zhang, K. Xu, Z. Xing, and X. R. Zhang, "A nanosized Y2O3-based catalytic chemiluminescent sensor for trimethylamine," |